The Premier League International Cup tie pits the Lisbon youngsters against our Academy side, kicking off at 19:00 GMT.
Of course, the clubs have previous links in the past, with Cristiano Ronaldo and Nani signed for the Reds, after breaking through Sporting's excellent youth system.
It promises to be another tough test against continental opposition, but United are currently in third spot in Group D, after three outings in the competition - a 2-1 win over Athletic Club, 4-1 loss to Anderlecht and 2-0 victory against Borussia Dortmund.
The top two teams qualify for the knockout stages and all the games are staged in England.